Assignment of 5-Hydroxytryptamine Receptor (HTR4) to human chromosome 5 bands q31→q33 by in situ hybridization

Assignment of WNT7B to human chromosome band 22q13 by in situ hybridization.

Assignment of murine placental cathepsin R to mouse chromosome bands 13B2-B3 by fluorescence in situ hybridization.

Recent studies revealed several essential roles for papainlike cysteine proteases in human or animal pathophysiology by their activities in degrading unwanted proteins, generating bioactive peptides, or dissolving important extracellular matrix-proteins, which leads to the pathogenesis of several human diseases (Chapman et al., 1997; Dickinson, 2002; Motyckova et al., 2002; Yan et al., 2003; Li...

5-Hydroxytryptamine 5-HT2A receptor and 5-hydroxytryptamine transporter polymorphisms in acute myocardial infarction.

This study was designed to analyse possible associations between DNA polymorphisms in the 5-hydroxytryptamine (5-HT; serotonin) 5-HT(2A) receptor and the 5-HT transporter (5-HTT) genes, and myocardial infarction (MI). 5-HT has been shown to be involved in cardiovascular pathophysiology. In addition to platelet aggregation and vascular contraction, 5-HT induces hyperplasia of artery smooth muscl...

Chromosomal assignment of the human thrombin receptor gene: localization to region q13 of chromosome 5.

A functional thrombin receptor (TR) structurally related to other members of the seven-transmembrane receptor family has been isolated from diverse cellular types intimately involved in the regulation of the thrombotic response. This receptor recapitulates many of the previously identified sequelae of thrombin-mediated cell activation phenomenon, and requires proteolytic cleavage for downstream...

Assignment of the human gene for the glucocorticoid receptor to chromosome 5.

Human lymphoblastic leukemia cells of line CEM-C7 are glucocroticoid-sensitive and contain glucocorticoid receptors of wild-type characteristics. EL4 mouse lymphoma cells are resistant to lysis by glucocorticoids due to mutant receptors that exhibit abnormal DNA binding. Hybrids between the two cell lines were prepared and analyzed with respect to glucocorticoid responsiveness and to receptor t...